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Lipid mediators of disease (Upcoming)
Cellular senescence in human disease (Apr 2018)
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Glia and Neurodegeneration (Sep 2017)
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JCI This Month
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JAK inhibitor treatment shows benefit for patients with interferonopathies
In this episode, Gina A. Montealegre Sanchez, Raphaela Goldbach-Mansky, and colleagues demonstrate that JAK1/2 inhibitor baricitinib improves clinical manifestations in a small cohort of patients with interferonopathies…
Published June 11, 2018
REV-ERBα controls the clock in the lung
In this episode, David Ray, Marie Pariollaud and colleagues identify REV-ERBα as a critical regulator of rhythmic inflammatory responses in the lung…
Published April 30, 2018
Immune tolerance-like pathway inhibits repair following white matter injury
Stephen Back and colleagues identify an immune tolerance-like pathway that prevents repair after white matter injury…
Published April 16, 2018
Vaginal epithelial shedding mediates ascending group B streptococcus infection
In this episode, Lakshmi Rajagopal provide evidence that group B streptococcus-induced exfoliation of the vaginal epithelium promotes ascending infection…
Published April 9, 2018
A role for plasminogen activator inhibitor type 1 in skin fibrosis
In this episode, Colin Jamora, Neha Pincha, and colleagues demonstrate a role for plasminogen activator inhibitor type 1 in driving fibrogenesis in a murine model of skin fibrosis…
Published March 26, 2018
CD163+ macrophages serve pathogenic role in atherosclerosis
In this episode Aloke Finn, Liang Guo and colleagues reveal that a population of alternatively activated CD163+ macrophages, previously thought to be atheroprotective, are instead pathogenic….
Published February 19, 2018
Tie1 deficiency limits cancer progression and metastasis
In this episode, Hellmut Augustin, Silvia La Porta, and colleagues link the orphan receptor Tie1 within intratumoral vasculature to cancer progression and metastasis…
Published January 22, 2018
Identification and characterization of GDF6 as a driver of melanoma
In this episode, Craig Ceol, Arvind Venkatesan, and colleagues identify GDF6-mediated BMP signaling as a driver of melanoma and potential therapeutic target...
Published December 4, 2017
Increased cardiomyocyte proliferation benefit depends on the heart injury
Gerd Hasenfuß, Loren Field, and Karl Toischer demonstrate that enhancing cardiomyocyte regeneration is beneficial for some, but not all, forms of heart failure…
Published October 30, 2017
Human breast milk-derived commensal limits pathogenic inflammation
Mansour Mohamadzadeh and colleagues identify a commensal Propionibacterium in human breast milk that ameliorates intestinal inflammation...
Published September 25, 2017
Copyright © 2018
American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)
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