[CITATION][C] 7-Nitroindazole: an inhibitor of nitric oxide synthase
PK Moore, PA Bland-Ward - Methods in enzymology, 1996 - Elsevier
Nitric oxide (NO) is synthesized from the semiessential amino acid L-arginine by the enzyme
nitric oxide synthase (NOS; EC 1.14. 13.39). The widespread distribution of NOS in
mammalian species coupled with its ability to alter a range of cellular and tissue functions
via activation of soluble guanylate cyclase (GC) has created considerable interest in the
identification of NOS inhibitors with potential clinical use in humans. 1, 2 Early studies
revealed that classic substrate-based inhibitors of this enzyme, for example, N% nitro-L …
nitric oxide synthase (NOS; EC 1.14. 13.39). The widespread distribution of NOS in
mammalian species coupled with its ability to alter a range of cellular and tissue functions
via activation of soluble guanylate cyclase (GC) has created considerable interest in the
identification of NOS inhibitors with potential clinical use in humans. 1, 2 Early studies
revealed that classic substrate-based inhibitors of this enzyme, for example, N% nitro-L …
