Japanese encephalitis virus up-regulates expression of macrophage migration inhibitory factor (MIF) mRNA in the mouse brain
T Suzuki, A Ogata, K Tashiro, K Nagashima… - … et Biophysica Acta (BBA …, 2000 - Elsevier
Macrophage migration inhibitory factor (MIF) is known as a proinflammatory cytokine,
glucocorticoid-induced immunomodulator, and pituitary hormone, and contributes to broad-
spectrum immune and inflammatory response. To investigate the expression of MIF in the
central nervous system in an event of viral infection, we evaluated MIF mRNA expression in
the mouse brain infected with Japanese encephalitis virus (JEV). In situ hybridization
revealed that MIF mRNA expression was significantly up-regulated in the whole brain by …
glucocorticoid-induced immunomodulator, and pituitary hormone, and contributes to broad-
spectrum immune and inflammatory response. To investigate the expression of MIF in the
central nervous system in an event of viral infection, we evaluated MIF mRNA expression in
the mouse brain infected with Japanese encephalitis virus (JEV). In situ hybridization
revealed that MIF mRNA expression was significantly up-regulated in the whole brain by …