[21] Linker for activation of T cells: Sensing redox imbalance
SI Gringhuis, FC Breedveld, CL Verweij - 2002 - Elsevier
Publisher Summary The chapter describes methods to determine the subcellular
localization, conformation, and phosphorylation status of linker for activation of T cells (LAT)
under variable intracellular redox conditions. LAT plays a crucial role in the proximal
signaling pathways induced by ligation of the TCR (T-cell receptor)/CD3 complex. LAT is
present in the so-called lipid rafts, glycolipid (GPI)-enriched microdomains, in the plasma
membrane of T lymphocytes and natural killer (NK) cells as an integral membrane protein …
localization, conformation, and phosphorylation status of linker for activation of T cells (LAT)
under variable intracellular redox conditions. LAT plays a crucial role in the proximal
signaling pathways induced by ligation of the TCR (T-cell receptor)/CD3 complex. LAT is
present in the so-called lipid rafts, glycolipid (GPI)-enriched microdomains, in the plasma
membrane of T lymphocytes and natural killer (NK) cells as an integral membrane protein …