[HTML][HTML] Suppression of macrophage eicosanoid synthesis by atherogenic lipoproteins is profoundly affected by cholesterol-fatty acyl esterification and the Niemann …
AR Leventhal, CC Leslie, I Tabas - Journal of Biological Chemistry, 2004 - ASBMB
Atheroma macrophages internalize large quantities of lipoprotein-derived lipids. While most
emphasis has been placed on cholesterol, lipoprotein-derived fatty acids may also play
important roles in lesional macrophage biology. Little is known, however, about the
trafficking or metabolism of these fatty acids. In this study, we first show that the cholesterol-
fatty acyl esterification reaction, catalyzed by acyl-CoA: cholesterol acyltransferase (ACAT),
competes for the incorporation of lipoprotein-derived fatty acids into cellular phospholipids …
emphasis has been placed on cholesterol, lipoprotein-derived fatty acids may also play
important roles in lesional macrophage biology. Little is known, however, about the
trafficking or metabolism of these fatty acids. In this study, we first show that the cholesterol-
fatty acyl esterification reaction, catalyzed by acyl-CoA: cholesterol acyltransferase (ACAT),
competes for the incorporation of lipoprotein-derived fatty acids into cellular phospholipids …