Effect of transgene copy number on survival in the G93A SOD1 transgenic mouse model of ALS
GM Alexander, KL Erwin, N Byers, JS Deitch… - Molecular Brain …, 2004 - Elsevier
Transgenic mice expressing multiple copies of the G93A mutant form of SOD1 develop
motor neuron pathology and clinical symptoms similar to those seen in patients with
amyotrophic lateral sclerosis (ALS). The phenotype of these mice is dependent on the
number of transgene copies in their genome. Changes in transgene copy number, although
rare, can sometimes occur while mating due to intra locus recombination events during
meiosis. The objective of this study was to develop a real time quantitative PCR method to …
motor neuron pathology and clinical symptoms similar to those seen in patients with
amyotrophic lateral sclerosis (ALS). The phenotype of these mice is dependent on the
number of transgene copies in their genome. Changes in transgene copy number, although
rare, can sometimes occur while mating due to intra locus recombination events during
meiosis. The objective of this study was to develop a real time quantitative PCR method to …