[HTML][HTML] NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia
L Qin, Y Liu, T Wang, SJ Wei, ML Block… - Journal of Biological …, 2004 - ASBMB
Parkinson's disease is characterized by the progressive degeneration of dopaminergic
neurons in the substantia nigra. We have previously reported that lipopolysaccharide (LPS)-
induced degeneration of dopaminergic neurons is mediated by the release of
proinflammatory factors from activated microglia. Here, we report the pivotal role of NADPH
oxidase in inflammation-mediated neurotoxicity, where the LPS-induced loss of nigral
dopaminergic neurons in vivo was significantly less pronounced in NADPH oxidase …
neurons in the substantia nigra. We have previously reported that lipopolysaccharide (LPS)-
induced degeneration of dopaminergic neurons is mediated by the release of
proinflammatory factors from activated microglia. Here, we report the pivotal role of NADPH
oxidase in inflammation-mediated neurotoxicity, where the LPS-induced loss of nigral
dopaminergic neurons in vivo was significantly less pronounced in NADPH oxidase …