[HTML][HTML] Molecular Cross-talk between the TRAIL and Interferon Signaling Pathways* 210
TRAIL/APO-2L induces apoptosis in a variety of transformed cells and has potential as an
anti-cancer therapeutic. The physiologic role of TRAIL is presumably more complex than
merely activating caspase-mediated cell death. To shed light into TRAIL-mediated signaling,
we used DNA microarrays to profile gene expression mediated by TRAIL in breast
carcinoma cells. Primary response genes induced by TRAIL included a number of known NF-
κB-dependent genes such as cIAP2, A20, and E-selectin. Remarkably, global transcriptome …
anti-cancer therapeutic. The physiologic role of TRAIL is presumably more complex than
merely activating caspase-mediated cell death. To shed light into TRAIL-mediated signaling,
we used DNA microarrays to profile gene expression mediated by TRAIL in breast
carcinoma cells. Primary response genes induced by TRAIL included a number of known NF-
κB-dependent genes such as cIAP2, A20, and E-selectin. Remarkably, global transcriptome …