[HTML][HTML] Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection
Double-stranded RNA (dsRNA) accumulates in virally infected cells, leading to induction of
genes encoding proteins involved in signaling, apoptosis, protein synthesis/processing, and
cell metabolism. Noxa is a BH3-containing mitochondrial protein that contributes to
apoptosis by disrupting mitochondrial outer membrane integrity. Here we demonstrate
potent induction of Noxa expression by exposure of cells to dsRNA, interferon (IFN), and
virus. Noxa induction was confirmed by using reverse transcriptase-PCR and immunoblot …
genes encoding proteins involved in signaling, apoptosis, protein synthesis/processing, and
cell metabolism. Noxa is a BH3-containing mitochondrial protein that contributes to
apoptosis by disrupting mitochondrial outer membrane integrity. Here we demonstrate
potent induction of Noxa expression by exposure of cells to dsRNA, interferon (IFN), and
virus. Noxa induction was confirmed by using reverse transcriptase-PCR and immunoblot …