Actin cytoskeleton organization in response to integrin‐mediated adhesion
P Defilippi, C Olivo, M Venturino… - Microscopy research …, 1999 - Wiley Online Library
P Defilippi, C Olivo, M Venturino, L Dolce, L Silengo, G Tarone
Microscopy research and technique, 1999•Wiley Online LibraryCell matrix adhesion regulates actin cytoskeleton organization through distinct steps, from
formation of filopodia and lamellipodia in the early phases of cell adhesion to organization of
focal adhesions and stress fibers in fully adherent cells. In this review, we follow the events
induced by integrin‐mediated adhesion, such as activation of GTPases Cdc42 and Rac and
their effectors and their role in actin polymerization leading to formation of lamellipodia and
filopodia and cell spreading. We also show that actin stress fiber and focal adhesion …
formation of filopodia and lamellipodia in the early phases of cell adhesion to organization of
focal adhesions and stress fibers in fully adherent cells. In this review, we follow the events
induced by integrin‐mediated adhesion, such as activation of GTPases Cdc42 and Rac and
their effectors and their role in actin polymerization leading to formation of lamellipodia and
filopodia and cell spreading. We also show that actin stress fiber and focal adhesion …
Abstract
Cell matrix adhesion regulates actin cytoskeleton organization through distinct steps, from formation of filopodia and lamellipodia in the early phases of cell adhesion to organization of focal adhesions and stress fibers in fully adherent cells. In this review, we follow the events induced by integrin‐mediated adhesion, such as activation of GTPases Cdc42 and Rac and their effectors and their role in actin polymerization leading to formation of lamellipodia and filopodia and cell spreading. We also show that actin stress fiber and focal adhesion formation following adhesion requires cooperation between integrin‐mediated signaling and additional stimuli, including activation of PKC, Rho GTPases, and PTKs such as p125Fak and Src. Microsc. Res. Tech. 47:67–78, 1999. © 1999 Wiley‐Liss, Inc.
Wiley Online Library