[HTML][HTML] Placental thrombosis and spontaneous fetal death in mice deficient in ethanolamine kinase 2
Y Tian, P Jackson, C Gunter, J Wang, CO Rock… - Journal of biological …, 2006 - ASBMB
Ethanolamine kinase catalyzes the first step in the CDP-ethanolamine pathway for the
formation of the major membrane phospholipid phosphatidylethanolamine (PtdEtn). In this
work, the predicted Etnk2 cDNA was established as a soluble protein with ethanolamine-
specific kinase activity that was most highly expressed in liver. Mice with an inactivated
Etnk2 gene were derived, and its absence reduced the rate of PtdEtn synthesis from
exogenous ethanolamine in hepatocytes. PtdEtn is a major precursor to phosphatidylcholine …
formation of the major membrane phospholipid phosphatidylethanolamine (PtdEtn). In this
work, the predicted Etnk2 cDNA was established as a soluble protein with ethanolamine-
specific kinase activity that was most highly expressed in liver. Mice with an inactivated
Etnk2 gene were derived, and its absence reduced the rate of PtdEtn synthesis from
exogenous ethanolamine in hepatocytes. PtdEtn is a major precursor to phosphatidylcholine …