[HTML][HTML] When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis
Y Pewzner-Jung, S Ben-Dor, AH Futerman - Journal of Biological Chemistry, 2006 - ASBMB
Ceramide is the key intermediate in the pathway of sphingolipid (SL) 2 biosynthesis (1) and
an important intracellular signaling molecule (2, 3). Ceramide consists of a sphingoid long
chain base to which a fatty acid is attached via an amide bond (Fig. 1). When the chemical
composition of SLs was first determined in the 1940s (4), stearic acid (C18: 0) was identified
as the major fatty acid attached to the sphingoid base. Later, with the development of more
sensitive techniques (5, 6), it became clear that mammalian SLs contain a wide variety of …
an important intracellular signaling molecule (2, 3). Ceramide consists of a sphingoid long
chain base to which a fatty acid is attached via an amide bond (Fig. 1). When the chemical
composition of SLs was first determined in the 1940s (4), stearic acid (C18: 0) was identified
as the major fatty acid attached to the sphingoid base. Later, with the development of more
sensitive techniques (5, 6), it became clear that mammalian SLs contain a wide variety of …