Stimulation of a neutral cholesteryl ester hydrolase by cAMP system in P388D1 macrophages
DI Goldberg, JC Khoo - Biochimica et Biophysica Acta (BBA)-Lipids and …, 1990 - Elsevier
Cholesteryl ester laden foam cells in atherosclerotic lesions derive, in part, from
macrophages. Mobilization of stored cholesteryl esters involves hydrolysis by a neutral
cholesteryl ester hydrolase. Incubation of intact P388D 1 macrophages with dibutyryl cAMP
in the presence of 1-methyl-3-isobutylxanthine resulted in a dose-dependent increase in
neutral cholesteryl ester hydrolase activity of up to 50%(ED 50= 0.1 mM). Incubation with
prostaglandin E 1 in the presence of 1-methyl-3-isobutylxanthine also increased neutral …
macrophages. Mobilization of stored cholesteryl esters involves hydrolysis by a neutral
cholesteryl ester hydrolase. Incubation of intact P388D 1 macrophages with dibutyryl cAMP
in the presence of 1-methyl-3-isobutylxanthine resulted in a dose-dependent increase in
neutral cholesteryl ester hydrolase activity of up to 50%(ED 50= 0.1 mM). Incubation with
prostaglandin E 1 in the presence of 1-methyl-3-isobutylxanthine also increased neutral …