[HTML][HTML] Carboxyl ester lipase expression in macrophages increases cholesteryl ester accumulation and promotes atherosclerosis
A Kodvawala, AB Ghering, WS Davidson… - Journal of Biological …, 2005 - ASBMB
Carboxyl ester lipase (CEL, also called cholesterol esterase or bile salt-dependent lipase) is
a lipolytic enzyme capable of hydrolyzing cholesteryl esters, triacylglycerols, and
phospholipids in a trihydroxy bile salt-dependent manner but hydrolyzes ceramides and
lysophospholipids via bile salt-independent mechanisms. Although CEL is synthesized
predominantly in the pancreas, a low level of CEL expression was reported in human
macrophages. This study used transgenic mice with macrophage CEL expression at levels …
a lipolytic enzyme capable of hydrolyzing cholesteryl esters, triacylglycerols, and
phospholipids in a trihydroxy bile salt-dependent manner but hydrolyzes ceramides and
lysophospholipids via bile salt-independent mechanisms. Although CEL is synthesized
predominantly in the pancreas, a low level of CEL expression was reported in human
macrophages. This study used transgenic mice with macrophage CEL expression at levels …