[HTML][HTML] Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility
VD Dixit, AT Weeraratna, H Yang, D Bertak… - Journal of biological …, 2006 - ASBMB
Originally thought of as a stomach-derived endocrine peptide acting via its receptors in the
central nervous system to stimulate food intake and growth hormone expression, ghrelin and
its receptor (growth hormone secretagogue receptor (GHS-R)) are widely expressed in a
number of organ systems, including cancer cells. However, the direct functional role of
ghrelin and its receptor in tumors of central nervous system origin remains to be defined.
Here, we demonstrate that the human astrocytoma cell lines U-118, U-87, CCF-STTG1, and …
central nervous system to stimulate food intake and growth hormone expression, ghrelin and
its receptor (growth hormone secretagogue receptor (GHS-R)) are widely expressed in a
number of organ systems, including cancer cells. However, the direct functional role of
ghrelin and its receptor in tumors of central nervous system origin remains to be defined.
Here, we demonstrate that the human astrocytoma cell lines U-118, U-87, CCF-STTG1, and …