Mitochondria-associated membranes or MAMs are specific regions within the endoplasmic
reticulum in close apposition to mitochondria. These contacts between both organelles are
involved in the regulation of several cellular functions such as the import of
phosphatidylserine into mitochondria from the ER for decarboxylation to
phosphatidylethanolamine, cholesterol esterification, calcium signaling, mitochondrial
shape and motility, autophagy, and apoptosis. Recently, MAM alterations have been …