In vitro studies of the impact of maribavir on CMV-specific cellular immune responses
D Stachel, T Stevens-Ayers, M Boeckh - Journal of Clinical Virology, 2016 - Elsevier
Background Ganciclovir has demonstrated immunosuppressive effects in vitro which may
lead to delayed cytomegalovirus (CMV)-specific immune reconstitution when the drug is
given prophylactically. Maribavir is a new and more potent anti-CMV drug that is under
evaluation for therapeutic use in transplant recipients. Objectives The objective of this study
was to evaluate the potential effect of maribavir on CMV-specific T cell function in
comparison to ganciclovir. Study design In ten immunocompetent CMV seropositive donors …
lead to delayed cytomegalovirus (CMV)-specific immune reconstitution when the drug is
given prophylactically. Maribavir is a new and more potent anti-CMV drug that is under
evaluation for therapeutic use in transplant recipients. Objectives The objective of this study
was to evaluate the potential effect of maribavir on CMV-specific T cell function in
comparison to ganciclovir. Study design In ten immunocompetent CMV seropositive donors …