Effects of antiepileptic drugs on 4-aminopyridine-induced epileptiform activity in young and adult rat hippocampus
Y Fueta, M Avoli - Epilepsy research, 1992 - Elsevier
Extracellular field potential recordings were used to study the effects of the antiepileptic
drugs (AEDs) carbamazepine (CBZ), phenytoin (PHT), phenobarbital (PhB) and valproic
acid (VPA) on the epileptiform activity evoked by 4-aminopyridine (4-AP, 50 μM) in the CA3
subfield of rat hippocampal slices obtained from young (8–23-day-old) and adult (> 60-day-
old) male rats. Ictal (duration: 3-2 rate of occurrence: 3–12× 10− 3 s− 1) and interjetai
(duration: 0.2–0.8 s; rate of occurrence: 0.2–0.8 s− 1) discharges were recorded in young …
drugs (AEDs) carbamazepine (CBZ), phenytoin (PHT), phenobarbital (PhB) and valproic
acid (VPA) on the epileptiform activity evoked by 4-aminopyridine (4-AP, 50 μM) in the CA3
subfield of rat hippocampal slices obtained from young (8–23-day-old) and adult (> 60-day-
old) male rats. Ictal (duration: 3-2 rate of occurrence: 3–12× 10− 3 s− 1) and interjetai
(duration: 0.2–0.8 s; rate of occurrence: 0.2–0.8 s− 1) discharges were recorded in young …
