Tuberculosis (TB) poses a great challenge to immunologists, as it represents a chronic
infection characterized by persistence of the pathogen despite development of antigen-
specific immune responses. Among the characteristics of adaptive immune responses to
Mycobacterium tuberculosis is a delay in the onset of detectable T-cell responses, in both
humans and experimental animals. Recent studies have revealed mechanisms that
contribute to this delay, including pathogen inhibition of apoptosis, delayed migration of …