Role of defensins in the pathogenesis of chronic lung allograft rejection
V Tiriveedhi, B Banan, S Deepti, A Nataraju… - Human immunology, 2014 - Elsevier
Chronic rejection predominantly manifested as bronchiolitis obliterans syndrome (BOS), still
remains a major problem affecting long-term outcomes in human lung transplantation (LTx).
Donor specific antibodies (DSA) and infiltration of neutrophils in the graft have been
associated with the development of BOS. This study determines the role of defensins,
produced by neutrophils, and its interaction with α-1-antitrypsin (AAT) towards induction of
airway inflammation and fibrosis which are characteristic hallmarks of BOS. Bronchoalveolar …
remains a major problem affecting long-term outcomes in human lung transplantation (LTx).
Donor specific antibodies (DSA) and infiltration of neutrophils in the graft have been
associated with the development of BOS. This study determines the role of defensins,
produced by neutrophils, and its interaction with α-1-antitrypsin (AAT) towards induction of
airway inflammation and fibrosis which are characteristic hallmarks of BOS. Bronchoalveolar …
