Single Dose Vaccination in Healthcare Workers Previously Infected with SARS-CoV-2 (preprint)
2021•pesquisa.bvsalud.org
ABSTRACT Coronavirus disease 2019 (COVID-19) vaccine shortages have led some
experts and countries to consider untested dosing regimens. We studied antibody
responses to a single dose of the Pfizer-BioNTech or Moderna vaccines in healthcare
workers (HCW) with laboratory-confirmed COVID-19 infection and compared to them to
antibody responses of HCW who were IgG negative to SARS-CoV-2 spike protein. HCW
with prior COVID-19 showed clear secondary antibody responses to vaccination with IgG …
experts and countries to consider untested dosing regimens. We studied antibody
responses to a single dose of the Pfizer-BioNTech or Moderna vaccines in healthcare
workers (HCW) with laboratory-confirmed COVID-19 infection and compared to them to
antibody responses of HCW who were IgG negative to SARS-CoV-2 spike protein. HCW
with prior COVID-19 showed clear secondary antibody responses to vaccination with IgG …
Abstract
Coronavirus disease 2019 (COVID-19) vaccine shortages have led some experts and countries to consider untested dosing regimens. We studied antibody responses to a single dose of the Pfizer-BioNTech or Moderna vaccines in healthcare workers (HCW) with laboratory-confirmed COVID-19 infection and compared to them to antibody responses of HCW who were IgG negative to SARS-CoV-2 spike protein. HCW with prior COVID-19 showed clear secondary antibody responses to vaccination with IgG spike binding titers rapidly increasing by 7 days and peaking by days 10 and 14 post-vaccination. At all time points tested, HCW with prior COVID-19 infection showed statistically significant higher antibody titers of binding and functional antibody compared to HCW without prior COVID-19 infection (p
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