The role of neutrophil elastase inhibitors in lung diseases
E Polverino, E Rosales-Mayor, GE Dale, K Dembowsky… - Chest, 2017 - Elsevier
In many respiratory diseases characterized by an intense inflammatory response, the
balance between proteolytic enzymes (proteases, including elastases) and their inhibitors
(proteinases inhibitors) is not neutral. Excess activity of neutrophil elastase (NE) and similar
proteases has been reported to cause tissue damage and to alter the remodeling process in
many clinical conditions such as pneumonia, respiratory distress, and acute lung injury
(ALI). Several experimental NE inhibitors have been tested in preclinical and clinical studies …
balance between proteolytic enzymes (proteases, including elastases) and their inhibitors
(proteinases inhibitors) is not neutral. Excess activity of neutrophil elastase (NE) and similar
proteases has been reported to cause tissue damage and to alter the remodeling process in
many clinical conditions such as pneumonia, respiratory distress, and acute lung injury
(ALI). Several experimental NE inhibitors have been tested in preclinical and clinical studies …
