Targeting the EphA4 receptor in the nervous system with biologically active peptides
KK Murai, LN Nguyen, M Koolpe, R McLennan… - Molecular and Cellular …, 2003 - Elsevier
EphA4 is a member of the Eph family of receptor tyrosine kinases and has important
functions in the developing and adult nervous system. In the adult, EphA4 is enriched in the
hippocampus and cortex, two brain structures critical for learning and memory. To identify
reagents that can discriminate between the many Eph receptors and selectively target
EphA4, we used a phage display approach. We identified three 12-amino acid peptides that
preferentially bind to EphA4. Despite lack of a common sequence motif, these peptides …
functions in the developing and adult nervous system. In the adult, EphA4 is enriched in the
hippocampus and cortex, two brain structures critical for learning and memory. To identify
reagents that can discriminate between the many Eph receptors and selectively target
EphA4, we used a phage display approach. We identified three 12-amino acid peptides that
preferentially bind to EphA4. Despite lack of a common sequence motif, these peptides …
