[HTML][HTML] The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated …
E Adam, KK Hansen, OF Astudillo, L Coulon… - Journal of biological …, 2006 - ASBMB
We investigated and compared the mechanisms by which two dust mite proteolytic
allergens, Der p 1 and Der p 3, and a peptide agonist of proteinase-activated receptor 2
(PAR 2 AP) trigger interleukin (IL)-8 release from human pulmonary epithelial cells (A549).
Although all three stimuli tested induced the up-regulation of IL-8 (mRNA and protein), the
Der p 1-mediated signaling events did not exactly match those induced by PAR 2 AP and
Der p 3. First, Der p 1 was less effective in stimulating IL-8 gene transcriptional activity than …
allergens, Der p 1 and Der p 3, and a peptide agonist of proteinase-activated receptor 2
(PAR 2 AP) trigger interleukin (IL)-8 release from human pulmonary epithelial cells (A549).
Although all three stimuli tested induced the up-regulation of IL-8 (mRNA and protein), the
Der p 1-mediated signaling events did not exactly match those induced by PAR 2 AP and
Der p 3. First, Der p 1 was less effective in stimulating IL-8 gene transcriptional activity than …