VHL takes HIF's breath away
W Krek - Nature cell biology, 2000 - nature.com
Nature cell biology, 2000•nature.com
Inactivation of the von Hippel–Lindau (VHL) tumour-suppressor protein (pVHL) is associated
with the von Hippel–Lindau cancer syndrome and the majority of kidney cancers. New
evidence suggests that pVHL has properties of an F-box protein that targets the α-subunits
of hypoxia-inducible factor (HIF)-1 for oxygen-dependent ubiquitination.
with the von Hippel–Lindau cancer syndrome and the majority of kidney cancers. New
evidence suggests that pVHL has properties of an F-box protein that targets the α-subunits
of hypoxia-inducible factor (HIF)-1 for oxygen-dependent ubiquitination.
Abstract
Inactivation of the von Hippel–Lindau (VHL) tumour-suppressor protein (pVHL) is associated with the von Hippel–Lindau cancer syndrome and the majority of kidney cancers. New evidence suggests that pVHL has properties of an F-box protein that targets the α-subunits of hypoxia-inducible factor (HIF)-1 for oxygen-dependent ubiquitination.
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