[HTML][HTML] Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4) …
Natural killer T (NKT) cells are important therapeutic targets in various disease models and
are under clinical trials for cancer patients. However, their function in obesity and type 2
diabetes remains unclear. Our data show that adipose tissues of both mice and humans
contain a population of type 1 NKT cells, whose abundance decreases with increased
adiposity and insulin resistance. Although loss-of-function of NKT cells had no effect on
glucose tolerance in animals with prolonged high fat diet feeding, activation of NKT cells by …
are under clinical trials for cancer patients. However, their function in obesity and type 2
diabetes remains unclear. Our data show that adipose tissues of both mice and humans
contain a population of type 1 NKT cells, whose abundance decreases with increased
adiposity and insulin resistance. Although loss-of-function of NKT cells had no effect on
glucose tolerance in animals with prolonged high fat diet feeding, activation of NKT cells by …