[PDF][PDF] Effects of TNF-α polymorphisms on asthma risk: a systematic review and meta-analysis
H Huang, W Nie, J Qian, Y Zang… - J Investig Allergol …, 2014 - esmonformacion.com
H Huang, W Nie, J Qian, Y Zang, J Chen, G Lai, T Ye, Q Xiu
J Investig Allergol Clin Immunol, 2014•esmonformacion.comBackground: Several studies have examined associations between TNF-α polymorphisms
and asthma risk, but the results have been conflicting. Methods: A search was performed of
the PubMed, EMBASE, and Wanfang databases. Data were extracted and pooled ORs with
95% CIs were calculated. Results: Fifty-four studies were included. A significant association
between the TNFA-308A/G polymorphism and asthma susceptibility was observed for AA+
AG vs GG (OR, 1.39; 95% CI, 1.23-1.58; P<. 001). This polymorphism was also significantly …
and asthma risk, but the results have been conflicting. Methods: A search was performed of
the PubMed, EMBASE, and Wanfang databases. Data were extracted and pooled ORs with
95% CIs were calculated. Results: Fifty-four studies were included. A significant association
between the TNFA-308A/G polymorphism and asthma susceptibility was observed for AA+
AG vs GG (OR, 1.39; 95% CI, 1.23-1.58; P<. 001). This polymorphism was also significantly …
Abstract
Background: Several studies have examined associations between TNF-α polymorphisms and asthma risk, but the results have been conflicting.
Methods: A search was performed of the PubMed, EMBASE, and Wanfang databases. Data were extracted and pooled ORs with 95% CIs were calculated.
Results: Fifty-four studies were included. A significant association between the TNFA-308A/G polymorphism and asthma susceptibility was observed for AA+ AG vs GG (OR, 1.39; 95% CI, 1.23-1.58; P<. 001). This polymorphism was also significantly associated with asthma risk in whites (OR, 1.47; 95% CI, 1.25-1.73; P<. 001), atopic asthma risk (OR, 1.38; 95% CI, 1.16-1.65; P<. 001), pediatric asthma risk (OR, 1.48; 95% CI, 1.23-1.79; P<. 001), and adult asthma risk (OR, 1.35; 95% CI, 1.21-1.52; P<. 001). There was also a significant association between the TNFA-857C/T polymorphism and asthma risk in the recessive model (OR, 1.25; 95% CI, 1.10-1.43; P<. 001). In the subgroup analyses, asthma risk was significantly increased in Asians (OR, 1.23; 95% CI, 1.07-1.41; P=. 004) and atopic individuals (OR, 1.33; 95% CI, 1.13-1.57; P<. 001). No significant association was found for the TNFA-238A/G polymorphism. There were insufficient data to evaluate the associations between TNFA-1031T/C and-863C/A polymorphisms and asthma risk. Conclusions: This meta-analysis suggests that TNFA-308A/G and-857C/T polymorphisms are risk factors for asthma.
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