[PDF][PDF] Variance stabilization applied to microarray data calibration and to the quantification of differential expression

W Huber, A Von Heydebreck, H Sültmann… - …, 2002 - researchgate.net
We introduce a statistical model for microarray gene expression data that comprises data
calibration, the quantification of differential expression, and the quantification of
measurement error. In particular, we derive a transformation h for intensity measurements,
and a difference statistic h whose variance is approximately constant along the whole
intensity range. This forms a basis for statistical inference from microarray data, and provides
a rational data pre-processing strategy for multivariate analyses. For the transformation h …