[HTML][HTML] A decade of molecular pathogenomic analysis of group A Streptococcus

JM Musser, SA Shelburne - The Journal of clinical …, 2009 - Am Soc Clin Investig
JM Musser, SA Shelburne
The Journal of clinical investigation, 2009Am Soc Clin Investig
Molecular pathogenomic analysis of the human bacterial pathogen group A Streptococcus
has been conducted for a decade. Much has been learned as a consequence of the
confluence of low-cost DNA sequencing, microarray technology, high-throughput
proteomics, and enhanced bioinformatics. These technical advances, coupled with the
availability of unique bacterial strain collections, have facilitated a systems biology
investigative strategy designed to enhance and accelerate our understanding of disease …
Molecular pathogenomic analysis of the human bacterial pathogen group A Streptococcus has been conducted for a decade. Much has been learned as a consequence of the confluence of low-cost DNA sequencing, microarray technology, high-throughput proteomics, and enhanced bioinformatics. These technical advances, coupled with the availability of unique bacterial strain collections, have facilitated a systems biology investigative strategy designed to enhance and accelerate our understanding of disease processes. Here, we provide examples of the progress made by exploiting an integrated genome-wide research platform to gain new insight into molecular pathogenesis. The studies have provided many new avenues for basic and translational research.
The Journal of Clinical Investigation