CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens

MS Vincent, X Xiong, EP Grant, W Peng… - The Journal of …, 2005 - journals.aai.org
MS Vincent, X Xiong, EP Grant, W Peng, MB Brenner
The Journal of Immunology, 2005journals.aai.org
Individual CD1-restricted T cells can recognize either endogenous or foreign lipid Ags, but
the extent to which the same CD1-restricted TCR can react to both self and microbial lipids is
unknown. In this study, we have identified CD1a-, CD1b-, and CD1c-restricted T cells from
normal human donors that induce cytolysis and secrete copious IFN-γ in response to self-
CD1 expressed on monocyte-derived dendritic cells. Remarkably, microbial Ags presented
by CD1 are even more potent agonists for these same T cells. The αβ T cell receptors from …
Abstract
Individual CD1-restricted T cells can recognize either endogenous or foreign lipid Ags, but the extent to which the same CD1-restricted TCR can react to both self and microbial lipids is unknown. In this study, we have identified CD1a-, CD1b-, and CD1c-restricted T cells from normal human donors that induce cytolysis and secrete copious IFN-γ in response to self-CD1 expressed on monocyte-derived dendritic cells. Remarkably, microbial Ags presented by CD1 are even more potent agonists for these same T cells. The αβ T cell receptors from such clones are diverse and confer specificity for both self-CD1 and foreign lipid Ags. The dual reactivity of these CD1-restricted cells suggests that the capacity for rapid responses to inflammatory stimuli without memory coexists with the capacity for strong Ag-specific responses and the generation of memory in vivo.
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