The role of the inflammasome in patients with autoinflammatory diseases
HM Hoffman, L Broderick - Journal of Allergy and Clinical Immunology, 2016 - Elsevier
Autoinflammatory diseases are disorders of the innate immune system, characterized by
systemic inflammation often driven by inflammasomes, and independent of infection and
autoreactive antibodies or antigen-specific T cells. These diseases are increasingly
recognized as disorders of immune dysregulation, presenting with a constellation of fevers,
rashes, and mucosal symptoms in many cases, which suggests that the
allergist/immunologist is the appropriate specialist for these patients. However, many …
systemic inflammation often driven by inflammasomes, and independent of infection and
autoreactive antibodies or antigen-specific T cells. These diseases are increasingly
recognized as disorders of immune dysregulation, presenting with a constellation of fevers,
rashes, and mucosal symptoms in many cases, which suggests that the
allergist/immunologist is the appropriate specialist for these patients. However, many …