Human kit ligand (stem cell factor) modulates platelet activation in vitro.

J Grabarek, JE Groopman, YR Lyles, S Jiang… - Journal of Biological …, 1994 - ASBMB
The human stem cell factor (SCF), also termed c-Kit ligand (KL), is a hematopoietic growth
factor produced by mesenchymal cells that induces proliferation of bone marrow progenitor
cells, megakaryocytes, and mast cells via interaction with c-Kit, its cognate receptor.
Expression of the c-kit gene was identified in human platelets by the polymerase chain
reaction technique. The presence of the c-Kit receptor was demonstrated by the specific
binding of 125I-KL/SCF to ADP-stimulated platelets. The identity of the c-Kit protein was …