NR4A orphan nuclear receptors in glucose homeostasis: a minireview

AF Close, C Rouillard, J Buteau - Diabetes & metabolism, 2013 - Elsevier
Type 2 diabetes mellitus is a disorder characterized by insulin resistance and a relative
deficit in insulin secretion, both of which result in elevated blood glucose. Understanding the
molecular mechanisms underlying the pathophysiology of diabetes could lead to the
development of new therapeutic approaches. An ever-growing body of evidence suggests
that members of the NR4A family of nuclear receptors could play a pivotal role in glucose
homeostasis. This review aims to present and discuss advances so far in the evaluation of …