[HTML][HTML] Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor α
JM Brandt, F Djouadi, DP Kelly - Journal of Biological Chemistry, 1998 - ASBMB
To explore the gene regulatory mechanisms involved in the metabolic control of cardiac fatty
acid oxidative flux, the expression of muscle-type carnitine palmitoyltransferase I (M-CPT I)
was characterized in primary cardiac myocytes in culture following exposure to the long-
chain mono-unsaturated fatty acid, oleate. Oleate induced steady-state levels of M-CPT I
mRNA 4.5-fold. The transcription of a plasmid construct containing the human M-CPT I gene
promoter region fused to a luciferase gene reporter transfected into cardiac myocytes, was …
acid oxidative flux, the expression of muscle-type carnitine palmitoyltransferase I (M-CPT I)
was characterized in primary cardiac myocytes in culture following exposure to the long-
chain mono-unsaturated fatty acid, oleate. Oleate induced steady-state levels of M-CPT I
mRNA 4.5-fold. The transcription of a plasmid construct containing the human M-CPT I gene
promoter region fused to a luciferase gene reporter transfected into cardiac myocytes, was …