Species differences in [11C] clorgyline binding in brain
JS Fowler, YS Ding, J Logan, RR MacGregor… - Nuclear medicine and …, 2001 - Elsevier
[11C] Clorgyline selectively binds to MAO A in the human brain. This contrasts with a recent
report that [11C] clorgyline (in contrast to other labeled MAO A inhibitors) is not retained in
the rhesus monkey brain [4]. To explore this difference, we compared [11C] clorgyline in the
baboon brain before and after clorgyline pretreatment and we also synthesized deuterium
substituted [11C] clorgyline (and its nor-precursor) for comparison.[11C] Clorgyline was not
retained in the baboon brain nor was it influenced by clorgyline pretreatment or by …
report that [11C] clorgyline (in contrast to other labeled MAO A inhibitors) is not retained in
the rhesus monkey brain [4]. To explore this difference, we compared [11C] clorgyline in the
baboon brain before and after clorgyline pretreatment and we also synthesized deuterium
substituted [11C] clorgyline (and its nor-precursor) for comparison.[11C] Clorgyline was not
retained in the baboon brain nor was it influenced by clorgyline pretreatment or by …