[HTML][HTML] Oral angiotensin-(1–7) prevented obesity and hepatic inflammation by inhibition of resistin/TLR4/MAPK/NF-κB in rats fed with high-fat diet

SHS Santos, JMO Andrade, LR Fernandes… - Peptides, 2013 - Elsevier
Obesity is characterized by a pro-inflammatory state commonly associated with type 2
diabetes and fat-liver disease. In the last few years, different studies pointed out the role of
Angiotensin (Ang)-(1–7) in the metabolic regulation. The aim of the present study was to
evaluate the effect of oral-administration of Ang-(1–7) in metabolism and inflammatory state
of high-fat feed rats. Twenty-four male Sprague Dawley rats were randomized into three
groups: High Fat Diet (HFD); Standard Diet (ST); High Fat Diet+ Angiotensin-(1–7)[HFD+ …