Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL
MS Topp, N Gökbuget, G Zugmaier… - Blood, The Journal …, 2012 - ashpublications.org
MS Topp, N Gökbuget, G Zugmaier, E Degenhard, ME Goebeler, M Klinger, SA Neumann…
Blood, The Journal of the American Society of Hematology, 2012•ashpublications.orgPersistence or recurrence of minimal residual disease (MRD) after chemotherapy results in
clinical relapse in patients with acute lymphoblastic leukemia (ALL). In a phase 2 trial of B-
lineage ALL patients with persistent or relapsed MRD, a T cell–engaging bispecific Ab
construct induced an 80% MRD response rate. In the present study, we show that after a
median follow-up of 33 months, the hematologic relapse-free survival of the entire evaluable
study cohort of 20 patients was 61%(Kaplan-Meier estimate). The hema-tologic relapse-free …
clinical relapse in patients with acute lymphoblastic leukemia (ALL). In a phase 2 trial of B-
lineage ALL patients with persistent or relapsed MRD, a T cell–engaging bispecific Ab
construct induced an 80% MRD response rate. In the present study, we show that after a
median follow-up of 33 months, the hematologic relapse-free survival of the entire evaluable
study cohort of 20 patients was 61%(Kaplan-Meier estimate). The hema-tologic relapse-free …
Abstract
Persistence or recurrence of minimal residual disease (MRD) after chemotherapy results in clinical relapse in patients with acute lymphoblastic leukemia (ALL). In a phase 2 trial of B-lineage ALL patients with persistent or relapsed MRD, a T cell–engaging bispecific Ab construct induced an 80% MRD response rate. In the present study, we show that after a median follow-up of 33 months, the hematologic relapse-free survival of the entire evaluable study cohort of 20 patients was 61% (Kaplan-Meier estimate). The hema-tologic relapse-free survival rate of a subgroup of 9 patients who received allogeneic hematopoietic stem cell transplantation after blinatumomab treatment was 65% (Kaplan-Meier estimate). Of the subgroup of 6 Philadelphia chromosome–negative MRD responders with no further therapy after blinatumomab, 4 are in ongoing hematologic and molecular remission. We conclude that blinatumomab can induce long-lasting complete remission in B-lineage ALL patients with persistent or recurrent MRD. The original study and this follow-up study are registered at www.clinicaltrials.gov as NCT00198991 and NCT00198978, respectively.
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