[HTML][HTML] The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter

A Ventura, L Luzi, S Pacini, CT Baldari… - Journal of Biological …, 2002 - ASBMB
The mammal Shc locus encodes three overlapping isoforms (46, 52, and 66 kDa) that differ
in the length of their N-terminal regions. p46/p52Shc and p66Shc have been implicated,
respectively, in the cytoplasmic propagation of growth and apoptogenic signals. Levels of
p66Shc expression correlate with life span duration in mice. p46Shc and p52Shc are
ubiquitously expressed, whereas p66Shc is expressed in a cell lineage-specific fashion.
However, the mechanisms underlying the regulation of Shc protein expression are …