Phospholipase A2 receptor autoantibodies and clinical outcome in patients with primary membranous nephropathy

E Hoxha, I Thiele, G Zahner, U Panzer… - Journal of the …, 2014 - journals.lww.com
Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults,
with an uncertain clinical outcome. The characterization of the phospholipase A 2 receptor
(PLA 2 R) as the major target antigen in primary MN and the detection of circulating
autoantibodies in these patients is a major advance in understanding this disease. To test
whether PLA 2 R antibody levels reflect disease activity or clinical outcome, we performed a
prospective multicenter study of 133 adult patients with primary MN and detectable serum …