[HTML][HTML] Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion …
P Brodin, MI de Jonge, L Majlessi, C Leclerc… - Journal of Biological …, 2005 - ASBMB
Proteins of the 6-kDa early secreted antigenic target (ESAT-6) secretion system-1 of
Mycobacterium tuberculosis are not only strongly involved in the anti-mycobacterial Th1-
host immune response but are also key players for virulence. In this study, protein
engineering together with bioinformatic, immunological, and virulence analyses allowed us
to pinpoint regions of the ESAT-6 molecule that are critical for its biological activity in M.
tuberculosis. Mutation of the Trp-Xaa-Gly motif, conserved in a wide variety of ESAT-6-like …
Mycobacterium tuberculosis are not only strongly involved in the anti-mycobacterial Th1-
host immune response but are also key players for virulence. In this study, protein
engineering together with bioinformatic, immunological, and virulence analyses allowed us
to pinpoint regions of the ESAT-6 molecule that are critical for its biological activity in M.
tuberculosis. Mutation of the Trp-Xaa-Gly motif, conserved in a wide variety of ESAT-6-like …