Redox balance underlies cellular homeostasis. Cancer initiation and progression has been
linked to the disruption of redox balance and oxidative stress. Recent findings exemplify the
distinctive roles of intracellular and extracellular redox state in the etiology and maintenance
of oxidative stress associated with malignancy and metastasis. Within these compartments,
redox sensitive cysteines play a crucial role in regulating cell signaling events that act to
promote the malignant phenotype via the activation of survival pathways, disruption of cell …