[HTML][HTML] Targeted mutagenesis of the angiogenic protein CCN1 (CYR61): Selective inactivation of integrin α6β1-heparan sulfate proteoglycan coreceptor-mediated …
SJ Leu, N Chen, CC Chen, V Todorovic, T Bai… - Journal of Biological …, 2004 - ASBMB
The matricellular protein CCN1 (CYR61) regulates multiple cellular processes and plays
essential roles in embryonic vascular development. A ligand of several integrin receptors,
CCN1 acts through integrin α 6 β 1 and heparan sulfate proteoglycans (HSPGs) to promote
specific functions in fibroblasts, smooth muscle cells, and endothelial cells. We have
previously identified a novel α 6 β 1 binding site, T1, in domain III of CCN1. Here we uncover
two novel 16-residue sequences, H1 and H2, in domain IV that can support α 6 β 1-and …
essential roles in embryonic vascular development. A ligand of several integrin receptors,
CCN1 acts through integrin α 6 β 1 and heparan sulfate proteoglycans (HSPGs) to promote
specific functions in fibroblasts, smooth muscle cells, and endothelial cells. We have
previously identified a novel α 6 β 1 binding site, T1, in domain III of CCN1. Here we uncover
two novel 16-residue sequences, H1 and H2, in domain IV that can support α 6 β 1-and …