Cannabinoid pharmacology: the first 66 years
RG Pertwee - British journal of pharmacology, 2006 - Wiley Online Library
RG Pertwee
British journal of pharmacology, 2006•Wiley Online LibraryResearch into the pharmacology of individual cannabinoids that began in the 1940s, several
decades after the presence of a cannabinoid was first detected in cannabis, is concisely
reviewed. Also described is how this pharmacological research led to the discovery of
cannabinoid CB1 and CB2 receptors and of endogenous ligands for these receptors, to the
development of CB1‐and CB2‐selective agonists and antagonists and to the realization that
the endogenous cannabinoid system has significant roles in both health and disease, and …
decades after the presence of a cannabinoid was first detected in cannabis, is concisely
reviewed. Also described is how this pharmacological research led to the discovery of
cannabinoid CB1 and CB2 receptors and of endogenous ligands for these receptors, to the
development of CB1‐and CB2‐selective agonists and antagonists and to the realization that
the endogenous cannabinoid system has significant roles in both health and disease, and …
Research into the pharmacology of individual cannabinoids that began in the 1940s, several decades after the presence of a cannabinoid was first detected in cannabis, is concisely reviewed. Also described is how this pharmacological research led to the discovery of cannabinoid CB1 and CB2 receptors and of endogenous ligands for these receptors, to the development of CB1‐ and CB2‐selective agonists and antagonists and to the realization that the endogenous cannabinoid system has significant roles in both health and disease, and that drugs which mimic, augment or block the actions of endogenously released cannabinoids must have important therapeutic applications. Some goals for future research are identified.
British Journal of Pharmacology (2006) 147, S163–S171. doi:10.1038/sj.bjp.0706406
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