[HTML][HTML] Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation
VN Patel, KM Likar, S Zisman-Rozen… - Journal of Biological …, 2008 - ASBMB
FGF10, a heparan sulfate (HS)-binding growth factor, is required for branching
morphogenesis of mouse submandibular glands (SMGs). HS increases the affinity of FGF10
for FGFR2b, which forms an FGF10· FGFR2b· HS ternary signaling complex, and results in
diverse biological outcomes, including proliferation and epithelial morphogenesis. Defining
the HS structures involved in specific FGF10-mediated events is critical to understand how
HS modulates growth factor signaling in specific developmental contexts. We used HS …
morphogenesis of mouse submandibular glands (SMGs). HS increases the affinity of FGF10
for FGFR2b, which forms an FGF10· FGFR2b· HS ternary signaling complex, and results in
diverse biological outcomes, including proliferation and epithelial morphogenesis. Defining
the HS structures involved in specific FGF10-mediated events is critical to understand how
HS modulates growth factor signaling in specific developmental contexts. We used HS …