Tissue-specific effect of estradiol on endothelial cell-dependent lymphocyte recruitment
HS Murphy, Q Sun, BA Murphy, RR Mo, J Huo… - Microvascular …, 2004 - Elsevier
Estrogen profoundly affects onset and severity of many immune-mediated diseases. In our
murine model of drug-induced autoimmunity, female-specific, estrogen-dependent increase
in splenic lymphocyte homing was directly implicated in increased disease severity. The
present study evaluated the effect of estradiol on microvascular endothelial cells from the
spleen compared to endothelial cells from the dermis, which has no disease manifestation in
this model. Estradiol increased spleen endothelial cell estrogen receptor (ER) alpha 2.9-fold …
murine model of drug-induced autoimmunity, female-specific, estrogen-dependent increase
in splenic lymphocyte homing was directly implicated in increased disease severity. The
present study evaluated the effect of estradiol on microvascular endothelial cells from the
spleen compared to endothelial cells from the dermis, which has no disease manifestation in
this model. Estradiol increased spleen endothelial cell estrogen receptor (ER) alpha 2.9-fold …