Altered coagulation and inflammation contribute to the pathogenesis of ischemic renal
injury. Thrombomodulin is a necessary factor in the anticoagulant protein C pathway and
has inherent anti-inflammatory properties. We studied the effect of soluble thrombomodulin
(sTM) in a hypoperfusion model of ischemic kidney injury. To markedly reduce infrarenal
aortic blood flow and femoral arterial pressures, we clamped the suprarenal aorta of rats,
occluding them 90%, for 60 min. Reversible acute kidney injury (AKI) occurred at 24 h in rats …