An adaptive immune response is initiated in the T cell area of secondary lymphoid organs,
where antigen-presenting dendritic cells may induce proliferation and differentiation in co-
localized T cells after T cell receptor engagement. The chemokines CCL19 and CCL21 and
their receptor CCR7 are essential in establishing dendritic cell and T cell recruitment and co-
localization within this unique microenvironment. It is shown that systemic application of a
fusion protein that consists of CCL19 fused to the Fc part of human IgG1 induces effects …