Synaptic Core Complex of Synaptobrevin, Syntaxin, and SNAP25 Forms High Affinity-SNAP Binding Site (∗)
HT McMahon, TC Südhof - Journal of Biological Chemistry, 1995 - ASBMB
SNAPs (soluble NSF attachment proteins) are cytoplasmic proteins that bind to specific
membrane receptors and mediate the membrane binding of NSF (N-ethylmaleimide-
sensitive factor), a protein that is required for membrane fusion reactions. Three synaptic
proteins in brain (SNAP25 (synaptosomal-associated protein of 25 kDa; no relation to the
SNAPs for NSF), synaptobrevin/VAMP, and syntaxin) were identified as SNAP receptors by
affinity chromatography on immobilized α-SNAP complexed to NSF (Söllner, T., Whiteheart …
membrane receptors and mediate the membrane binding of NSF (N-ethylmaleimide-
sensitive factor), a protein that is required for membrane fusion reactions. Three synaptic
proteins in brain (SNAP25 (synaptosomal-associated protein of 25 kDa; no relation to the
SNAPs for NSF), synaptobrevin/VAMP, and syntaxin) were identified as SNAP receptors by
affinity chromatography on immobilized α-SNAP complexed to NSF (Söllner, T., Whiteheart …
