[HTML][HTML] Transient expression of PU. 1 commits multipotent progenitors to a myeloid fate whereas continued expression favors macrophage over granulocyte …
Z McIvor, S Hein, H Fiegler, T Schroeder… - Experimental …, 2003 - Elsevier
OBJECTIVE: The Ets-family transcription factor PU. 1 is expressed specifically in the
hematopoietic system, in which it is absolutely required for the generation of B lymphocytes
and macrophages. In contrast, overexpression of PU. 1 blocks terminal differentiation of the
erythroid lineage, in which it can act as an oncogene. In this study we used a multipotential
progenitor cell line to examine the effects of PU. 1 overexpression on myeloerythroid
commitment within a single model system. MATERIALS AND METHODS: PU. 1 cDNA was …
hematopoietic system, in which it is absolutely required for the generation of B lymphocytes
and macrophages. In contrast, overexpression of PU. 1 blocks terminal differentiation of the
erythroid lineage, in which it can act as an oncogene. In this study we used a multipotential
progenitor cell line to examine the effects of PU. 1 overexpression on myeloerythroid
commitment within a single model system. MATERIALS AND METHODS: PU. 1 cDNA was …
