[HTML][HTML] Interferon-γ mediates suppression of erythropoiesis but not reduced red cell survival following CpG-ODN administration in vivo
N Thawani, M Tam, KH Chang, MM Stevenson - Experimental hematology, 2006 - Elsevier
OBJECTIVE: Cytokines released during inflammatory processes have been proposed to
play a central role in mediating mechanism (s) leading to anemia. Here, we used CpG-ODN
to investigate the effects of a pro-inflammatory response on the pathophysiological
processes leading to anemia. METHODS: Naïve and erythropoietin (EPO)-treated mice were
injected for 2 days with 100 μg CpG-ODN or control ODN and the effects on the course of
red blood cell (RBC) and reticulocyte counts, RBC turnover, and EPO-stimulated maturation …
play a central role in mediating mechanism (s) leading to anemia. Here, we used CpG-ODN
to investigate the effects of a pro-inflammatory response on the pathophysiological
processes leading to anemia. METHODS: Naïve and erythropoietin (EPO)-treated mice were
injected for 2 days with 100 μg CpG-ODN or control ODN and the effects on the course of
red blood cell (RBC) and reticulocyte counts, RBC turnover, and EPO-stimulated maturation …
